Long-Term Use of Ticagrelor in Patients with Prior Myocardial ...
WEBMay 7, 2015 · Furthermore, the PEGASUS-TIMI 54 trial evaluated two doses of ticagrelor therapy: 90 mg twice daily, which has been studied previously in acute coronary syndromes, 11 and 60 mg twice daily,...
Ticagrelor with or without Aspirin in High-Risk Patients after PCI
WEBSep 26, 2019 · In a double-blind trial, we examined the effect of ticagrelor alone as compared with ticagrelor plus aspirin with regard to clinically relevant bleeding among patients who were at high risk for...
Ticagrelor in Patients with Stable Coronary Disease and Diabetes
WEBSep 1, 2019 · When the results of the PEGASUS–TIMI 54 trial showed a better side-effect profile for the 60-mg twice-daily dose of ticagrelor than the 90-mg dose, 8,10 we lowered the dose of ticagrelor in...
Long‐Term Ticagrelor in Patients With Prior Coronary Stenting …
WEBAug 21, 2021 · In this prespecified analysis from the PEGASUS‐TIMI 54 trial, we have shown that patients with prior coronary stenting enrolled 1 to 3 years following an MI remain at elevated risk for cardiovascular death, MI, or stroke and derive benefit from long‐term therapy with ticagrelor regardless of prior stent type.
PEGASUS-TIMI 54 - TIMI STUDY GROUP
WEBPEGASUS – TIMI 54 was a randomized, double-blind, placebo-controlled trial to assess the prevention of thrombotic events with ticagrelor on a background of aspirin therapy in patients with history of myocardial infarction.
Long-term use of ticagrelor in patients with prior myocardial ...
WEBMay 7, 2015 · In patients with a myocardial infarction more than 1 year previously, treatment with ticagrelor significantly reduced the risk of cardiovascular death, myocardial infarction, or stroke and increased the risk of major bleeding. (Funded by AstraZeneca; PEGASUS-TIMI 54 ClinicalTrials.gov number, NCT012 ….
Efficacy and Safety of Ticagrelor Over Time in Patients With ... - PubMed
WEBSep 12, 2017 · Methods: The PEGASUS-TIMI (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis In Myocardial Infarction) 54 trial randomized patients with prior MI (median 1.7 years prior) to ticagrelor 90 mg, ticagrelor 60 mg, or placebo on a …
Long-Term Ticagrelor in Patients With Prior Coronary Stenting in …
WEBSep 7, 2021 · Methods and Results Patients in PEGASUS-TIMI 54 had a myocardial infarction 1 to 3 year prior and were randomized 1:1:1 to ticagrelor 60 or 90 mg BID or placebo. The primary end point was a composite of cardiovascular death, myocardial infarction, or stroke (major adverse cardiovascular events).
Reduction in Subtypes and Sizes of Myocardial Infarction With ...
WEBNov 20, 2018 · PEGASUS‐TIMI 54 randomized patients with prior MI to ticagrelor 60 mg twice daily, ticagrelor 90 mg twice daily, or placebo, all on a background of low‐dose aspirin. The protocol was approved by the relevant ethics committee at each participating site.
Prevention of Cardiovascular Events in Patients With Prior Heart …
WEBDec 18, 2019 · The PEGASUS-TIMI 54 trial showed that among aspirin-treated individuals with prior MI, ticagrelor reduced cardiovascular events.