Top of the bill are Manchester United who face a daunting trip to buoyant Aston Villa on Sunday afternoon. Unai Emery has worked miracles at Villa Park and the home side will come into this fixture off the back of their astonishing win over Bayern Munich in midweek.

Premier League's record goalscorer Alan Shearer believes Chelsea's Cole Palmer could fetch huge transfer free if they cashed in given the England star's stunning form

Get exclusive match odds tips from Alan Shearer as the Betfair Ambassador gives his Premier League predictions for Matchday 6 - Saturday 28 September to Monday 30 September

After rescuing a point against Arsenal last weekend, Manchester City face a tough trip to Newcastle without injured midfielder Rodri, who appears set to miss the rest of the season. The Gunners, meanwhile, entertain struggling Leicester while the big game of the weekend sees Manchester United entertain Spurs at Old Trafford.

Aston Villa host the German giants in the second round of the Champions League league phase on Wednesday evening

After a busy midweek of European and Carabao Cup action, the Premier League takes centre stage again this weekend. All eyes will be on the Etihad Stadium come Sunday when the top two go head-to-head.