Louisville’s first three games, all of which were wins, ranged from relatively easy to incredibly easy. Facing Notre Dame in South Bend would be a different type of task. While the Cardinals held their own against the Irish, they ultimately suffered their first loss of the season, 31-24.

The Fighting Irish (4-1) relied on a last-minute defensive stand to hand the Cardinals their first loss of the season

A wacky first quarter propelled No. 16 Notre Dame to an early 14-point lead over No. 15 Louisville, and though the Cardinals wouldn't go away, it was the Fighting Irish who came out on top in South Bend.